Endocrine Abstracts

Introduction: Metabolic syndrome (MS) is a clustering of risk factors. Endothelial dysfunction has been reported in patients with MS and even in healthy obese individuals with a normal metabolic profile. Sympathetic activity commonly is increased in obese hypertensives, and moxonidine, is found to be effective in lowering blood pressure and improving insulin sensitivity. The aim of this study is to evaluate the efficacy of moxonidine on endothelial dysfunction in insulin-resis...

Introduction: Obesity prevalance is rapidly increasing all over the world and become a serious health problem. There is a significant correlation between serum calcium levels and body fat mass. It was indicated that when plasma calcium levels increase, BMI decrease however, insulin, total cholesterol, and triglycerides levels increase. In this study, it was investigated the relationship between plasma calcium levels and cardiovascular risk factors and metabolic syndrome parame...

Aims: Bening and malignant thyroid nodules are the most common lesions of endocrine glands. Some molecular markers; Mut-S homolog-2 (MSH2) and Mut-L-homolog-1 (MLH1) are the two of DNA repair proteins and metil guanin–DNA-metil transferase (MGMT) is the DNA repair enzymes have been studied. In this study, our aim is to evaluate MSH2, MLH1, and MGMT levels in papillary thyroid cancer (PTC), multinodular colloidal goitre (MNG), and chronic lymphocytic thyroiditis (CLT) and ...

Introduction: It was shown that a relationship between uric acid and cardiovascular diseases, and hyperuricemia is associated with systemic inflammation. But, determination of uric acid is widely available and inexpensive, it has been overlooked as a marker of systemic inflammation and metabolic disturbances. In this study, we aimed to evaluate uric acid value and its association with inflammation and metabolic disturbances in overweight and obese Turkish women.<p class="a...

Aim: Increased levels of fasting parathyroid hormone(PTH) have been hypothesized to influence increased levels of body fat mass. Preliminary studies show that serum PTH levels are higher in obese than in non-obese young adults and decline with weight loss. In the present study, it was aimed to evaluate relationship between antropometric and metabolic risk parameters and PTH levels in Turkish women.Materials and methods: Analyses were performed on 710 Tur...

Aim: Serum calcium levels have a relation glucose homeostasis and weight management, and controversies in findings. This study carried out relationship between serum calcium levels and various metabolic parameters in obese Turkish Women.Materials and methods: Subjects for this study were 3544 overweight or obese Turkish women with mean level of serum calcium 9.4 md/dl. According to mean calcium level, they divided group I having >9.4 mg/dl and group ...

Introduction: Age at menarche reflects various health aspects including the timing of sexual maturation, growth and nutritional status, and enviromental conditions. This study carried out assesment obesity risk and the relationship between obesity, metabolic parameters and age at menarche in a series of Turkish women.Materials and methods: In a survey of obesity outpatient clinic, 4212 women who have mean age 38.5±12.1 years and ages at menarche bet...

Homozygous familial hypercholesterolemia (HoFH) represents a potentially fatal condition that is caused by low density lipoprotein (LDL) cholesterol receptor deficiency. Statins alone are not effective in HoFH. In recent years, semiselective or selective LDL cholesterol apheresis systems have been shown to prolong life. However, applying LDLC apheresis therapy, recent evidence also suggests that more intense LDL cholesterol reduction is associated with more clinical benefit. E...

C-reactive protein (CRP) is a non-specific but sensitive marker of underlying systemic inflammation. High CRP levels correlate with risk for future cardiovascular events. Statins can lower the circulating levels of CRP. In contrast, the evidence that fibrates lower CRP levels is very limited. This retrospective study evaluates the effect of micronised fenofibrate on plasma levels of CRP in patients with combined hyperlipidemia.Sixty-four patients with co...

Introduction: Serum ferritin concentration was found to be related with dyslipidemia, hypertension and abdominal adiposity. The aim of this study is to evaluate the correlations between serum ferritin concentrations and metabolic risk markers in obesity.Methods: Obese 534 women were enrolled into the study. The patients were divided into three tertiles according to the serum ferritin concentrations. The mean serum ferritin concentration was 9.96±4.1...